He avoided telling her about his immortality, telling Richie he did not want to go through another Tessa. She was targeted by Kalas in his campaign to destroy those MacLeod cared about before killing him. Medical orders supposedly signed by her that had led to the deaths of patients, however, were proved forgeries by MacLeod who realized what was happening.
Kalas lured her to his theater during his ambush for MacLeod. She arrived during their battle, and witnessed Duncan's fall from the lighting catwalk, and his death on the auditorium seats below. Richie hustled her out of the building before MacLeod recovered, however, and Mac then retreated to Paris, leaving her believing him dead.
Eventually, MacLeod decided he cared enough about her to tell her the truth, and with Joe Dawson's help, let her know he was alive and got her to Paris. During the time she had been grieving his death, however, she had become pregnant by a friend who comforted her loss in Seacouver. MacLeod, with trepidation, decided he could raise her child as his own.
During the events of Mortal Sins she decided to leave Duncan because after what she witnessed the brutality of the evil Immortal Ernst Daimler, she had wanted Duncan to kill him, even wished to do it herself. She could not let that kind of thinking overwhelm her, saying, "I'm a doctor, I save lives, I don't take them. I can't start wanting to take them." Heartbroken, they went their separate ways.In Reunion, Anne was working when Kenny returned, calling for help. While she treated his wound, she found that it had healed and realized that he was an immortal. She called Duncan and he arrived to take Kenny from the hospital. Later, Anne went to see how Kenny was doing and met Amanda who was staying with Duncan. The two women bond over Anne's pregnancy and become friends.
Months later, in Seacouver, she was nearing the end of her pregnancy when she responded to a bombing in a subway. MacLeod and Richie also responded looking for her. They managed to get in, but MacLeod then sent Richie back to the surface with an injured person, while he went in search of Anne. When he eventually tracked her down she was trapped with another woman, Karen, and in labor. With MacLeod's support and Karen's help, she gave birth to a baby girl, whom she named Mary, after MacLeod's mother.
Duncan made a gift of the house he had been renovating to Anne and her daughter.